The following essay is printed with permission from The conversationan online publication covering the latest research.
In a regular blood test that has been unique, French scientists recognize the New and unique group of world. The only known carrier is a woman from Guadeloupe whose blood is very unusual that doctors can not find a corresponding donor.
Discovering 48 recognized blood groups, called “Gwada-negative”, began reacting to the blood of the blood of the woman against every own brothers. As a result, it is impossible to find an appropriate blood donor for him.
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Many people know their type of blood – A, B, AB or O-companion if they are RH-positive or negative. But these familiar categories (those letters are further “positive” or “negative”) represent two of the dozen blood group systems that determine the ability of abbreviation. Each system reflects the subtle but important differences in proteins and sugar with the strata of our red blood cells.
To resolve the mystery of incompetent blood in Guadeloupian uncomfortable, scientists become a genetic analysis. Using the full exempic exempa – a technique checking all 20,000-plus man’s genes – they discovered a mutation of a geni.
This gene produces an enzyme responsible for adding a specified sugar to an important molecule of cell membranes. Lost sugar changes the structure of a molecule over the red blood cells. Kini nga pagbag-o naghimo sa usa ka bag-ong antigen – usa ka hinungdan nga bahin nga naghubit sa usa ka grupo sa dugo – nga miresulta sa usa ka hingpit nga bag-ong klasipikasyon: Gwada-positibo (nga kulang) o -negative (kulang kini).
Using the gene editing technology, the team confirmed their discovery by recread mutation to a lab. So the red blood cells from all blood donors tried is positive in the Gwada – Guadeloupean patient is the only known Gly-negative person on the planet.
The implications of discovery exceeds blood transfusions. The patient suffered from gentle intellectual deficiency, and depressed, lost two children’s birth – consequences that could be connected to his unique genetic mutation.
The enzyme produced by the geni pigz operates at the last stage of construction of a complex molecule called GPI (glycosylphosphatitlinositol). The previous research shows that people with defects to other enzymes needed for GPI Assembly experience neurological problems from delays in the development of seizures. Silences are common to females inherited diseases.
Although the patient in the Caribbean is the only person in the world to this type of blood type, the delay in progress and intellectual disorders with the defects of the enzymes needed on the GPI line.
Gwada’s discovery emphasizes wonders and challenges of human genetic variation. Blood groups improved as protection against contagious diseases (many bacteria, viruses and parasites using blood group molecules as cells entering cells). This means that your blood type can influence your order of some diseases.
But extreme rarity creates medicine dilemmas. French researchers recognize that they do not know what happens when the Gwada – cannot be judged blood transferred to Guadeloupian woman. Although there are other gwades-negative people with, they are harder to find. It is also unclear if they can be blood donors.
This purpose is to the truth toward a futuristic solution: Lab blood cells. Scientists have already worked Growing red blood in the blood From stem cells that may have been changed genetically to match Ulah-rare blood types. In the case of the Gwada, researchers can be artificially creating the Gwada-negative red blood cells through genen gen.
A growing field
The Gwada includes 47 other blood group systems RECOGNIZED by the International Society of Dood Traftfusion. As most blood group systems, discovered in a hospital hospital where technicians are trying to find the corresponding blood for a patient.
The name reflects Caribbean roots in the case: Gwada is slang for someone from Guadeloupe, which gives this group of battlefield.
As genetic order can be more advanced and widely used, researchers expect to know more blood species. Every discovery expands our understanding of human difference and raises fresh challenges for transit and other types of personal medicine.
This article was originally published in The conversation. Read the Original article.
