Melanoma is a type of skin cancer that can spread elsewhere in the body
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Despite many decades of effort and many human tests, only one virus designed to kill cancers approved by US and European regulators. But a second gets the green light at the end of the month, after taking good results for the treatment of melanoma, a worst kind of skin CANCER.
A genetically revised virus of herpes, called rp1, Injection to the boils In 140 people with advanced melanoma for whom patterned treatments have failed. Participants also took a drug called Nivolumab, designed to enhance resistance to resistant to boils.
By 30 percent of the treats, tumpled plants, including non-injections. In half of these cases, the boils disappear completely.
“Half of the responders have complete answers, which means perfect disappearance to all boils,” as Gino Kim Sa At the University of Southern California. “We are very pleased with these results.” Other options for treating people at this episode do not work and have worse effects, he said.
A later test period associated with 400 people today, but RP1 can be approved by the US administration (FDA) to repair Nivoumbab long time, has been told New Scientist. “The FDA should give us a decision by the end of the month.”
It is known for over a century of Virus infections sometimes help treat cancersBut deliberate imposing people with “wild” viruses are very dangerous. In the 1990s, biologists began Genetically modifications to viruses to try to better treat cancersBut healthy cells are not harmful.
These viruses are designed to work in two ways. First, by directly affect cancer cells and kill them by breaking them. Second, by prompting a response to immune aiming at all cancer cells, wherever they are in the body.
For example, a herpes simplex Bills Known as T-vec, or sad, modified to perform infected tumor cells called GM-CSF, among other changes. In 2015, T-VEC approved US and Europe for treating poor melanoma.
But T-VEC is not widely used, says in, in part because it is only attempted and approved for injecting boiling boils. Most people with advanced melanoma have deep tumors, he said.
In RP1, the decision was made to try it again with deeper tumors. RP1 is a herpes simplex virus, such as T-vec, but has been improved in many ways. In particular, it produces tumor cells that enter the neighboring cells, which helps viruses spread the boils and raise resistance resistance.
There is no direct comparison with T-VEC tests and RP1, but RP1 is more likely to arouse shaking all the boils, not only injected. “That indicates a more powerful systematic effect.”
Therefore, in anticipated RP1 is more likely to be used than T-VEC when approved. It will also give a great enthusiasm for the full idea of using cancer kill viruses, he said. “I look forward to having more interest.”
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