Do we grow new brain cells as adults? The answer seems to be yes

We also grow up with new brain cells while adults are the subject of a continuous and constant steady debate. Now, the evidence suggests we can. It helps answer one of NeuroscienceThe most controversial questions and positioned some speculation that the process will be exploited by treating conditions such as depression and alzheimer disease.

New neurons forms through a process called neurogenesis of children, as well as adult mice and Macaques. It involves stem cells repeatedly developing the so-called progenitor cells to form non-perishable neurons that eventually becomes fully developed.

Know before human adults Stem Cells and Not too neurons to hippocampus. This region of the brain, which is important for learning and memory, a primary area for children’s neurogenesis and a few adult animals, but adult cells have not seen here in adults. “This link is lost, and that is one of the main arguments against new neurons that form the adult brain,” as Evgenia jumps In the Netherlands Institute for Neuroscience, not included in new research.

To find this link, Jonas Frisén In the Karolinska Institute of Sweden and his teammates at first set about making machine learning models that can accurately identify progenitor cells. It involves collecting hippocampus samples from six small children whose brain has been donated to their parents for research when they died.

Researchers trained artificial intelligence models to identify self-based cells based on the activity of about 10,000 genes, using data obtained from samples. “In childhood, the progenitor cells were similar to what they did in rats, so that we could easily recognize it,” Frisén said. “(The idea is) We can get the molecules of molecules of childhood progenitors and use them to identify these adults’ cells.”

To test the models, the team recognizes progenitor cells in hippocampus samples from young mice. Models correctly target 83 per cent of progenitor cells and improperly covered another type of cell as a progenitor with no 1 percentage of time. In another test, the models are properly predicted a nearly unplugged cells in samples of a mature cortex, a region of the brain where there is no evidence of people’s neurogenesis.

“They really really appreciate their model by going from human child’s data, with mouse data and then the mature man’s data,” as Sandine Thuret In the King’s College London.

Once this validation is completed, researchers can test if the neurogenesis occur in human adults, by using hippocampus models in 14 and 78 when they died.

At first, they first carry a step which increased their difficulties to catch the progenitor cells, which First studies suggest that adults are rare. The team uses an antibody to choose for brain cells dividing during death, including nonuranal cells such as immunity cells. It helps participate in common nonuruuran cells, such as mature neurons, which are easier to find.

Then they feed data related to genetic activity from dividing cells in models. “They enhance dividing cells, allow them to find unique cells to miss whether you put all the cells,” as Song of hongjun at the University of Pennsylvania. It does not do in first studies, he said.

The team found progenitor cells at nine donors. “In the rodents, it is well known that the causes of environment and genetic affect many neurogenesis, so what I think is the differences between people and genetic and frisé causes.

The results are strongly suggested by Thuret, Song and Salta that adult neurogeneses are true. “It helps field make an important step ahead, because it’s added to the missing link,” Salta said.

“Neurons are real born from the cell division that is at the time of maturity – this is exactly what this paper does,” Thuret said.

This may be a day that can study differences in adults’ neurogenesis and no conditions affect the BRAINSAs with depression and Alzheimer’s, says Thuret. Perhaps drugs that raise this process may reduce symptoms, he’s wonders.

but Jon Arellano At Yale University says that even if new brain cells act in adults, it may be very small of them available in therapeutic use. Though Thuret thinks this is not a problem. “In rats we find that you only need a small amount to be important for learning (and) memory,” he said.