People with type 1 diabetes do not produce enough insulin to regulate their blood sugar
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Researchers have 3D printed devices made of insulin cells. These devices can make a long-term treatment for Type 1 diabetes that will allow people to produce self insulin – without needing developmental operations.
Because people with type 1 diabetes do not produce enough insulin to regulate their blood sugar, they should always manage their condition, usually with dietary care and dieting. A long term treatment involves moving human islets – insulin-growing cells that usually grow in pancreas – from donors. But like an organ transplant, it requires surgery.
“The present practice is to inject these islets to man by the liver vein portal,” as Quentin Perrier In the Wake Forest Institute for Regenerative Medicine in North Carolina. However, about half-held islets can easily lose their work, which means people must undergo multiple transitions to make effective treatment.
If the islets can be placed directly under the skin, surgery is not only unresponsive, but it is also fruitless stress and inflammation that has shortened the life of the cells.
“Higher density (in islets), the small size of the device you must plant in the patient,” as Adam Feinberg In the Carnegie Mellon University in Pennsylvania and the Biotech Company Fluidferform Bio in Massachusetts.
To achieve high density, the perrier and his companion copies of islets from a “Biolink” made by human pancreatic tissue and alginate, a carbohydrate species obtained from seaweeded. The cells that make insulin mixed with this material.
“We put this Biimbink to (man) islet in a syringe, and we publish a special motive (with it),” Perrier said. This porous grid is designed to allow new blood vessels to grow and through structure.
In the lab, this technique “works great”, says the perrier, known about 90 percent of the islets of islets have survived and moves up to three weeks. “The next challenge is to validate this search to vivo.“Perrier and his companions showed their research on the European Society for organ transplantation (esot) 2025 meeting in London on July 29,
Feinberg and his 3D companions also publish their own islets. Their technique is to create a framework by printing cells and collagen directly to a hydrogel polymer – “differently like 3D printing in the hair gel”, he said. The International Pancreas & Islet Transplant Assocation 2025 meeting at Pisa, Italy was 16 June 16 June. In the diabetes labet rats, islets restored normal control of glucose to six months.
Feinberkr said Perrier’s job “definitely promised” but that the natural innovation of the human tissue used in the islands can provoke a living body. “It’s like getting a transplant organ,” he said. “On one side, the material can be better material. On the flip side, it variable and difficult to get, and that is a difficult problem of solving.”
To avoid transit issues, both feinberg and perrier saying cell cell therapies represent the future of Type 1 Diabetes. Using stem cells in the 3D printing process – instead of the cells they use today – solve many issues at one time, they say.
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