Description of the raised ovaries of a person with polycticstic ovary syndrome
Science / Difference photo library
Polycycystic ovary syndrome can be passed through families by chemical tags that change the structure of the DNA, suggested that drugs that change the condition.
People with polycystic ovary syndrome (PCOS) have at least two of three key features: High levels of male sex hormones such as testosterone, irregular periods or none at all, and a build-up of immature eggs – that appears like cysts – on their ovaries.
The situation always runs families, but it’s not clear how it is inherited. “About 25 to 30 (genetic mutations) were involved in PCOS, but that explains a small portion of heritage,” as Elisabet Stener-Victorin In the Karolinska Institute in Sweden.
Mouse studies suggest that changes to Epigenetic scores – Chemical tags repeated genes and unchanged sequences in DNA – can also have a paper. Thought most marks have been erased when egg shapes, but others are considered to remain, a potential field.
To find out if it happens with people’s PCOS, Qianshu Zhu In Chongqing Medical University in China and his companions checked with epigenetic marks of eggs and 3-day embryos donated to 133 people with PCOS and 95 unconditionally. “It has never done this in this way of man’s material,” Stener-Victorin said.
It reveals a link between a donor with PCOS and changes to patterns of three classes of epigenetic marks with eggs and embryo. Two of these scores formed genes by making DNA coil more restricted around proteins called histories, which help package them within the cells. It produces the genetic code of DNA which is less accessible to the molecules that transcribe it to RNA, an important step in making proteins. The third type of score moves genes by repairing DNA coils.
Join, changes to PCOS changes in epigenetic changes changed the metabolism of eggs and embryos, which suggest that they can raise the risk of PCOS in PCOS. But additional studies should explore how they affect the PCOS symptoms of the children of mice and people, as Stillen-Victorin. “Now, we just know that scores are different; it doesn’t mean they have a negative effect,” he said.
In another experiment, the team uses medicine to reverse epigenetic changes, which suggest that it reduces the risk of PCOS. “If we confirm that historical scores have changed the rounds of PCOS to the next generation, we have a strong target for avoidance,” Zhu said to a release of news. What else, says the clinics can use PCOS-related markings to select the health embryos during Vitro Fertilization.
Zhu shows the results of the annual meeting of the European Society of Human Reproduction and Embrito in Paris on July 1.
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