The potential effect of Leiurus Quinquestriatus Scorpion Venom as an anti-parasitic drug for TricHinello

Abstract

Trichinella Spiralis a parasitic nematode with a complicated life cycle and recognized as an important public health concern. Although albendazole (abz) and mebidazole are widely used to treat trichinellosis, natural products can offer more effective alternatives. This study evaluates the effectiveness of Leiurus Quinquestriatus Venom (LQV) as an anti-parasitic agent against T. Spalalis infection of rats. The median fatal dose (ld₅₀) of the LQV first specified in adult male CD1 mice, sixty mice have been assigned to four groups (n = 15): non-treated control; infected, unchanged control; Infected mice treated by Oral to ABZ (50 mg / kg); and infected rats treated with intraperitone with LQV (0.03 mg / kg; 1/10 ld₅₀) for 15 days. In 7- and 35-day post-infections, the worms of adult and muscular Laral loads were evaluated. Serum Interleukin-4 (IL-4) and interaction-10 (IL-10) levels measured, and histopathological and imminiohistichicical analysis were made of intestinal tissues and mostly. As compared with uneven controls, the LQV treatment caused a 55% reduction of adult mature worms and 49% reduction in muscular worms. Both Abz and LQV significantly lower IL-4 and IL-10 levels. History and Immunoohistochemical findings found that LQVV ameliorated tissue infection tissue tissue and pathology tissue. These results suggest that LQV produces antiparasitic and immunomodulatory effects, which can represent a promised natural choice for TRICHINELLISSIS for TRICHINELLISSIS for TRICHINELLISSIS.