Meuk7-3 description and Silico design its analogs for enhanced therapeutic and therapeutic potential

Kv1.3 channels are made up of diseases of autoimmune and neuroinflamatory. Scorpion Venom is an excellent source of inhibitors for Kv1.3. Kv1.3, a pivotal voltage-gated potassium channel, exited as a critical therapeutic target for resisting autoimmume and rheumatoid arthritosis diseases. Some studies tried to discover the selected threads that focus on kv1.3 channels, but it was still difficult. Here, we present a groundbreaking nationality to a powerful Peptide potassium channel blocker, MEUK7-3, from the scorpion thread, MESEBOURHUS CRUCITTITI. While similar to other blockers in Kv1.3, Meuk7-3 in LYS19 left in LYS19 can enhance the channel for the channel. So, we were redesigned by meuk7-3 and created three equals, meuk7-3- a, meuki7-3-S, to improve KV1-3. Interaction evaluation with kv1.3 revealed that meuk7-3 and all its designed analogous could of kv1.3’s pore through the interaction of lys19 of the peptide with tyr447, tyr797, and tyr1497, critical residues located at the channel pore of KV1.3.However, the stability of the interaction of designed peptides with Kv1.3 more than meuk7-3. Affinity Affinity analysis reveals that all designed peptides have better sealing in Kv1.3 than Meuk7-3. Among three equals, one found that there are better medicinal properties and interaction situations, including binding of Kv1.3, compared to Meuk-3 native. These findings provide new data for designing more effective kv1.3 inhibitors through computational tools for the treatment of autoimmemune diseases and even experimental tests should prove it.