Human DNA in natural condition within cells (left) compared to state of eight hours after being infected with cold disease virus (right)
Esther Gonzalez Almela and Álvaro Castells García
The virus usually causes cold wounds begins to resort our genome for an hour of infection to develop self-growth, that scientists can take advantage of intense cases.
Billions of people around the world have infectionknown as herpes simplex virus type 1 (HSV-1), although many of them do not know. It can spread by contacting other cold sores, saliva or even undoubted skin in the mouth.
After the host’s advancement of the host, the virus hurts the nucleus, where the genetic material is stored in the strands of buttocks. These strands wrap proteins, with some regions forming tight coils, without active genes, where the wider loops, where genes are active. In these looser regions, proteins can prevent and transcribe DNA to molecule Rana, encoding for proteins that continue to run cells.
Shown before the genome man studies turned out to be more restricted coilding During the HSV-1 infection, which Can break the cell functionBut it is unclear why this coiling occurs.
To know more, Alvaro Castells-Garcia In the center for genomic regulation of baromic, Spain, and his team can imagine HSV-1 as it experienced a micros cells, using a microscope that can take 3500 times than a strand of hair. “This is a higher resolution than most studies,” says Castells-Garcia.
They know that within a time entering the virus cellsIt has already stolen the transcription proteins away from human genome, confirming the results of the first study.
But they also show that this thief is the reason for hosting the DNA together to reinstate 30 percent of its pre-infection in eight hours infections.
The virus is also contacted in the specified regions of the host genome encoding for transcription proteins that it steals, which are reinforced by the genes that can help.
“We used to think that it was talking to our genome random,” As the team member Ester González-Almelaalso in the center for genomic regulation. “But the virus is able to contact our own genome in specific regions, and these regions often conduct genes involved in maintaining infection, making viral rna and protein.”
On another part of the study, researchers find an experimental cancer drug to prevent one of the transcript proteins that steals it with HSV-1 stabs in the HSV-1 cells. It suggests that medicine helps to treat HSV-1 of people with severe cold wounds or those with a suppressed reslection of immune and more to experience complications, as González-Almela. Cases of depressing often left to clear themselves.
It can still work against others VirusesLike Adenovirus, causing colds, and Varicella Zoster virus, which causes CNOCPOX. “Other viruses similar to HSV-1 can use similar methods,” as Benjamin Krishna at the University of Cambridge. “There is a possibility that it is (kinds of experimental drugs) can also take care of the same,” he said.
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