Kidney disease can lead to high blood pressure and infection
Mohammed haneffaa nizamudeen / getty images
Body damage caused by the most common type of inherent kidney disease is thought to be unchanged. But now, animal studies suggest that correcting responsible mutations through Crispr Gene editing can be returned to some of them.
POLYCYCYSTIC KIDNEY (PKD) is caused by many changes in the kidneys over time. “It seems that you don’t change that even if you rebuked (the mutation),” Michael Kaminski said in Charité – Berlin University of Medicine in Germany. “But now as the disease can be more plastic than any way is appreciated before.”
The PKD leads the cysts full of fluids greater than hours, which form kidneys and is always the liver. These organs finally failed, which means people need dialysis or a transplant to survive. But even before the kidneys fail, their damaged and swollen condition can cause many other issues, from High blood pressure and infections of excessive pressures of other organs.
With the form of adult in the disease, which Estimated to affect 12 million people around the worldCysts may not grow enough enough to make the symptoms until people in their 30s, which time there are many changes in kidneys and liver.
Today, Kaminski’s team uses a CRISPR form called base edit to correct a mutation of a gene called PKD1 which causes the disease of mice.
The methods used by his team means Mutantice Gene is generally corrected in the liver, and the number and size of the cysts there reject treatment. There are also signs of the development of kidneys, says Kaminski.
Separate, Xiaogang Device ‘S team in Mayo Clinic in Rochester, Minnesota, did the same study Using methods better target kidneys. It suggests that the number and size of cysts can also be reduced, says Li.
The two sets of researchers are used Viruses to provide the machinery to the gene editing. This can be an issue if the repetition of doses is necessary, because the resistance of the resistance of viruses can prevent treatment from working. “It’s a worry,” said Li. “But so far, based on animal model, resistant response is limited.”
Replacing viruses with lipid nanoparticles as used by MRNA vaccines can avoid the potential resistance issue by saying effectively, as Kaminski. “But I think a way to bring (lipid nanoparticles) by urethra can be more realistic,” he said.
Another issue is that the read edit can only correct the mutations of the sumer and therefore do not work for people whose illness is caused by a longer mutation. But Li said he achieved the same consequences in a technique called principal edit, which could correct longer mutations.
This work will be published in a science journal soon, he said, then he focuses on moves to people. “If our paper was published, I will try to organize a small clinical test,” he said.
Especially, finding teams that can change the PKD should encourage more research in this procedure. Currently, approved treatment is a drug called Tolvaptan, which is a bit slowly developing and requires people to drink many liquids.
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