Incidental increase and rate mortality in malignant boils highlight their great impact on human health. Bacteria therapy emerges as a promising avenue of oncological research. Our lab has lonely an analgesic-anti-tumor peptide from the poison of Buthus Marketsii Karsch (BMK Agap), a high scorpion venom peptide, showing extraordinary anti-tumor activity. However the limited bioavailability of Peptides has a challenge for their therapeutic efficacy. To solve this challenge, we focus on the development of delivery of To your Agap to develop anti-tumor effectiveness. We are engineered E. coli K12 to make Tsypu strain, not only express To your Agap, but there is also lytic capabilities. TSYPU co-culture with Murine Syrjast Cancer 4T1 cells in Vitro shows its potential as a drug delivery platform. Additional development includes TSYPU encapsulation with Nanogold particle, resulting in TSYPU @ AU Strain. In Vivo experiments revealing the TSPU @ AU shows a significant anti-tumor effect, dealing with overcoming the acidic gastrointestinal environment. In summary, our study emphasizes the recovery of TSYPU bacteria as carriers for To your Delivery of Agap, offers a promising method for the argument of the drill delivery systems in oncology bacteria. This method has a lot of potential to invade the field and enables further investigation in future studies.
Zhang, Y., Li, X., Tian, C. et al. Drinking sales bacteria in Scorpion Venom Peptide Agriculture for target breast cancer therapy. Curr Microbiol 82323 (2025). https://doi.org/10.1007/s00284-025-04289-9
